Follicular Fluid FISH

Follicular fluid is a novel source of gonadal cells for detection of low-grade mosaicism in the ovaries. All women with unexplained infertility undergoing IVF could be studied to determine the chances of a successful pregnancy. If there is evidence of gonadal mosaicism, the chances of a live birth could be low. Mosaicism for the X chromosome detected rapidly by FISH on follicular fluid cells can be one more indication for preimplantation genetic diagnosis (PGD) in the same and subsequent cycles.